Volume 3, Issue 4, July 2015, Page: 117-119
Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet
Ercan Keskin, Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Deniz Uluisik, Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Mehmet Altin, School of Physical Education and Sports, University of Selcuk, Konya, Turkey
Received: Jun. 9, 2015;       Accepted: Jun. 29, 2015;       Published: Jul. 8, 2015
DOI: 10.11648/j.avs.20150304.14      View  4624      Downloads  119
Abstract
L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.
Keywords
L-carnitine, Cholesterol, Liver Enzymes, Rat
To cite this article
Ercan Keskin, Deniz Uluisik, Mehmet Altin, Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet, Animal and Veterinary Sciences. Vol. 3, No. 4, 2015, pp. 117-119. doi: 10.11648/j.avs.20150304.14
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