Volume 3, Issue 4, July 2015, Page: 113-116
Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet
Ercan Keskin, Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Deniz Uluisik, Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Mehmet Altin, School of Physical Education and Sports, University of Selcuk, Konya, Turkey
Received: Jun. 9, 2015;       Accepted: Jun. 26, 2015;       Published: Jul. 7, 2015
DOI: 10.11648/j.avs.20150304.13      View  4172      Downloads  142
Abstract
This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.
Keywords
L-carnitine, Cholesterol, Antioxidants, Lipid Peroxidation, Rat
To cite this article
Ercan Keskin, Deniz Uluisik, Mehmet Altin, Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet, Animal and Veterinary Sciences. Vol. 3, No. 4, 2015, pp. 113-116. doi: 10.11648/j.avs.20150304.13
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