Volume 1, Issue 2, June 2013, Page: 7-12
Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver
Maria L. Perepechaeva, Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Russia
Alevtina Yu. Grishanova, Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Russia
Received: May 7, 2013;       Published: Jun. 10, 2013
DOI: 10.11648/j.ab.20130102.11      View  2247      Downloads  82
Abstract
During hypothermia, most cellular processes are inhibited, including expression of numerous genes. A small number of special genes are activated, which code for proteins participating in cold acclimation of the cell. We previously uncovered a paradoxical phenomenon: cytochrome P450 subfamily enzymes (CYP1A) in rat liver are not inhibited but activated by systemic cooling. In the present study, we have investigated the influence of cold exposure on the activity and expression level of the CYP1A proteins in a different organ, rat lungs, and did not find any changes either in the activity or quantity of these enzymes. We hypothesize that this phenomenon is due to the absence of an endogenous intermediary of CYP1A induction in the rat lung, in contrast to the liver.
Keywords
CYP1A Activation, Cold, Rat Liver, Rat Lung, Tocopherol, α-TBP
To cite this article
Maria L. Perepechaeva, Alevtina Yu. Grishanova, Comparison of the Effects of Cold on Cytochromes Р450 1А in the Rat Lungs Versus Liver, Advances in Biochemistry. Vol. 1, No. 2, 2013, pp. 7-12. doi: 10.11648/j.ab.20130102.11
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